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Advancing our understanding of the mechanisms that govern organelle and lipid homeostasis in health and disease
The Olzmann Research Group integrates systems biology, chemical biology, and cell biology to uncover the fundamental principles that govern organelle function and lipid homeostasis. Our research focuses on the mechanisms that regulate lipid storage within lipid droplets and the processes underlying oxidative lipid damage during ferroptosis. By unraveling the biochemical pathways involved, we aim to identify novel therapeutic targets and develop strategies to manipulate these pathways for clinical benefit.
RECENT NEWS
May 28, 2025
Congrats to Amalia on her new publication out in PNAS – "Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1"
May 7, 2025
Congrats to Mike on the publication of a News & Views in Nature! "Small molecule degrades lipids to kill cancer cells"
April 25, 2025
New collaborative manuscript with the Nomura lab out as a bioRxiv preprint! "DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders"
April 4, 2025
New collaborative paper with the Zoncu lab out in Science! "Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins"
January 6, 2025
Congrats to Mike on his new manuscript out as a bioRxiv preprint – "FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis"
FEATURED ARTICLES

Li et al.
Nature Chem Biol 2022
Bersuker et al.
Nature 2019


Hendricks et al.
Cell Chem Biol 2023
Reveals selenium metabolism and ribosome stalling as ferroptosis vulnerabilities
Identifies the CoQ oxidoreductase FSP1 as a powerful ferroptosis suppressor in cancer
Identifies FSP1 inhibitors that sensitize cancer cells to ferroptosis
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